HORDB

ID: hor005694
Uniprot ID: P10601
Protein name: Pancreatic prohormone (Pancreatic polypeptide) (PP)
Gene name: Ppy
Organism: Mus musculus (Mouse)
Family: NPY family
Source: Animal
Expression: pancreatic islets of Langerhans
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm

Sequence: APLEPMYPGDYATPEQMAQYETQLRRYINTLTRPRY
Length: 36(30-65)
Propeptide: MAVAYCCLSLFLVSTWVALLLQPLQGTWGAPLEPMYPGDYATPEQMAQYETQLRRYINTLTRPRYGKRAEEENTGGLPGVQLSPCTSPPVGLIPCSAPWS
Signal peptide: MAVAYCCLSLFLVSTWVALLLQPLQGTWG
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005694_AF2.pdb

hor005694_ESM.pdb

Mass:	495934	Formula:	C193H294N52O58S2
Absent amino acids:	CFHKSVW	Common amino acids:	PY
pI:	6.64	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	7
Hydrophobicity:	-107.22	Boman Index:	-9232
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	51.67
Instability Index:	6020.28	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86